Aashakiran Fertility World and IVF Center in Mohali, Kharar, Chandigarh, Punjab
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Noninvasive Prenatal Testing (NIPS).

Noninvasive Prenatal Testing (NIPS).

Noninvasive Prenatal Testing (NIPS)

NIPS analyses cell-free DNA (cDNA) from the fetus that circulates in the mother's blood Detects fetal chromosomal aneuploidies from the mother's blood

of DNA comes from apoptotic cells derived from:

Maternal Circulation

  • Adipocytes
  • White Blood Cells

Fetal

  • Placental cells (trophoblasts) In the maternal circulation

Who should get an NIPS?

Advanced maternal age, High risk by biochemical screening

Pregnant women who wish to have screening for Trisomy 13, 18 & 21

Previous history of pregnancy loss

Patients that are not eligible for invasive testing

- Placental previa, symptoms of miscarriage, HBV or HIV patients

Recommendation for the use of NIPS

Non-invasive prenatal testing for trisomies 13, 18 & 21 should be an option available to women at increased risk in lieu of amniocentesis.

Pretest counselling of these women should include a discussion of the limitations of non-invasive prenatal testing.

No irrevocable obstetrical decision should be made in pregnancies with a positive non-invasive prenatal testing result without confirmatory invasive diagnostic testing.

Why should you perform an NIPS?

  • NIPS is non-invasive and therefore poses no risk to the mother or baby.
  • NIPS could give you an early option to know more about the genetic health of your baby.
  • Compared to traditional biochemical screening tests, NIPS offers higher accuracy and lower false positive rates.
  • Invasive diagnostic procedures such as amniocentesis or chorionic villus sampling can be avoided, which carry a ~1% risk of miscarriage.

Choose NIPS

Early Screening: - Can be carried at early gestational age of 11 weeks and allows sufficient time for further confirmatory investigation.

Low Risk: - Only 10 ml blood is required.

Highly Effective: - Can detect Aneuploidy even at Fetal Fraction (cDNA) as low as 4%.

High Accuracy: - Massive Parallel Sequencing of cDNA to generate 20 million reads per sample.

NIPS may not be suitable for:

Gestational age less than 10 weeks - due to low fetal fraction of cell free DNA in maternal blood Not recommended for women with multiple gestations - since it is not possible to determine which of the two fetuses is affected. If the parents are carriers of chromosomal abnormalities - interference in data interpretation – false positive Chromosomal structural changes, translocations or mutations in single genes cannot be detected by NIPS.